Evidence supporting the use of: 5-Hydroxytryptophan (5-HTP)
For the health condition: Sugar Cravings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor to serotonin, a neurotransmitter involved in regulating mood, appetite, and satiety. The rationale for using 5-HTP to help manage sugar cravings arises from scientific observations that low serotonin levels can increase carbohydrate cravings and intake, likely as a compensatory mechanism to boost serotonin production in the brain. Supplementing with 5-HTP may increase central serotonin levels, which in turn could promote satiety and reduce cravings for sugary or carbohydrate-rich foods.

Several small clinical studies have investigated this effect. For example, a randomized controlled trial published in the American Journal of Clinical Nutrition (1992) found that obese women given 5-HTP consumed fewer calories, particularly from carbohydrates, compared to placebo. Another study in non-obese women reported similar results, with 5-HTP reducing caloric and carbohydrate intake and subjective appetite. However, these studies are generally limited by small sample sizes, short durations, and variable quality.

Overall, the evidence for 5-HTP’s effectiveness in reducing sugar cravings is preliminary but promising. It is not a traditional remedy for sugar cravings, but its use is supported by plausible biological mechanisms and some scientific studies. However, larger and longer-term trials are needed to confirm efficacy and safety. The current rating reflects modest scientific support, but 5-HTP should be used with caution due to potential side effects and interactions, especially with other serotonergic agents.

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