Evidence supporting the use of: Acemannan
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acemannan, a polysaccharide derived from Aloe vera, has been studied for its potential wound healing properties, including in the context of surgical recovery. Scientific research indicates that acemannan can promote wound healing through several mechanisms: it stimulates macrophage activity, enhances fibroblast proliferation, and increases the production of growth factors such as VEGF and TGF-β1, all of which are relevant to tissue repair. Animal studies and in vitro experiments have demonstrated that acemannan accelerates wound closure, supports collagen deposition, and may reduce inflammation. Some small clinical trials and case reports also suggest benefits in oral surgery (e.g., post-extraction sockets) and chronic wound care. However, most of the clinical evidence is preliminary, with small sample sizes and methodological limitations. Systematic reviews generally conclude that while the biological plausibility is strong and initial results are promising, more robust human trials are needed to establish efficacy and optimal usage in surgical patients. In summary, there is some scientific basis for acemannan’s use in supporting post-surgical healing, but the evidence is not yet strong or conclusive.

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Products containing Acemannan

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