Evidence supporting the use of: Hyaluronic acid
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hyaluronic acid (HA) is scientifically validated for use in supporting healing from surgery, particularly in fields such as ophthalmology, orthopedics, and oral surgery. HA is a naturally occurring glycosaminoglycan found in connective tissues, synovial fluid, and skin, and plays a critical role in tissue hydration and repair. In the context of surgery, HA has been used as a topical agent, injectable, or as a component of wound dressings and surgical adjuncts.

In ophthalmic surgery, HA-based viscoelastic substances are routinely used to protect ocular tissues and promote healing after procedures like cataract extraction. In orthopedic surgery, intra-articular injections of HA are sometimes used post-operatively to reduce inflammation and support joint recovery, though evidence for pain relief and functional improvement varies. Dental and oral surgeons use HA gels and films to improve healing of oral mucosa and extraction sites, with some studies showing reduced pain and faster epithelialization.

Systematic reviews and meta-analyses suggest HA can modulate inflammation, enhance cell migration, and promote tissue regeneration, contributing to improved healing outcomes. However, the strength of evidence varies by application and surgical context, with the most robust support in ophthalmology and oral surgery. While not a universal standard for all types of surgery, its use is supported by both biochemical rationale and clinical research, warranting a moderate evidence rating.

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