Evidence supporting the use of: Hyaluronidase
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hyaluronidase is an enzyme that breaks down hyaluronic acid, increasing tissue permeability and facilitating the diffusion of injected substances. Its use in surgery is scientifically validated, though its applications are mostly adjunctive rather than directly reparative. In surgical settings, hyaluronidase is commonly used to enhance the absorption and dispersion of local anesthetics, especially in ophthalmic and plastic surgery. By degrading hyaluronic acid in the extracellular matrix, it helps fluids and medications spread more efficiently through tissues, which can lead to improved anesthesia and potentially less tissue trauma during injection. This may indirectly support healing by reducing the likelihood of tissue necrosis due to local anesthetic pooling, and by minimizing post-operative swelling. However, hyaluronidase is not directly used to promote or accelerate surgical wound healing. Its role is supportive, primarily to assist drug delivery or to manage complications such as hematoma or extravasation of drugs. Some studies suggest that by reducing edema and allowing for better distribution of fluids, hyaluronidase may indirectly contribute to a more favorable healing environment, but there is no direct evidence that it speeds up tissue repair or regeneration. Overall, its use in the context of surgery is scientifically justified for specific supportive purposes, but not as a primary agent for healing.

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Products containing Hyaluronidase

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