Evidence supporting the use of: Hydroxyproline
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydroxyproline is an amino acid derivative found predominantly in collagen, which is a major structural protein in connective tissues such as skin, tendons, and ligaments. Its presence and metabolism are considered important indicators of collagen synthesis and turnover, processes crucial for wound healing, especially after surgery. There is some scientific basis for considering hydroxyproline supplementation or monitoring in the context of surgical healing, primarily because collagen deposition is a key step in tissue repair.

Some studies have explored the use of hydrolyzed collagen or specific amino acid mixtures (including hydroxyproline) to support wound healing, and there is evidence that increased hydroxyproline content in tissues correlates with improved healing in animal models and some human studies. However, most of the clinical data are limited, generally of low to moderate quality, and often involve small sample sizes or lack rigorous controls. There is not robust, high-level clinical evidence that oral hydroxyproline supplementation alone significantly accelerates surgical healing in humans, and it is not a standard of care. Hydroxyproline is often used as a biomarker to assess collagen content in healing tissues rather than as a direct supplement.

In conclusion, while the rationale for hydroxyproline in supporting surgical wound healing is scientifically plausible and supported by some experimental data, the direct clinical evidence for its supplemental use in this context is limited. More large-scale, well-controlled human trials are needed to establish its efficacy.

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Products containing hydroxyproline

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