Evidence supporting the use of: Insulin-like growth factor
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Insulin-like growth factor (IGF), particularly IGF-1, has been studied for its role in tissue repair and wound healing, which are critical components of recovery following surgery. IGF-1 is a hormone similar in structure to insulin and is known to promote cell proliferation, differentiation, and survival. Several preclinical studies have demonstrated that IGF-1 can enhance healing of skin, bone, and other tissues by stimulating protein synthesis and cell growth, and by promoting angiogenesis (formation of new blood vessels). For example, animal models have shown accelerated wound closure and improved tissue regeneration with IGF-1 administration.

However, the translation of these findings into clinical practice is limited. Clinical trials in humans have been small and often inconclusive, with some studies suggesting potential benefits in specific contexts (e.g., chronic wounds, burns), but not establishing clear guidelines for use in routine surgical recovery. Moreover, concerns about potential adverse effects, such as stimulating unwanted cell proliferation or cancer risk, have limited its widespread clinical adoption.

In summary, while the scientific rationale for using IGF-1 to support surgical healing is strong based on experimental and animal research, clinical evidence in humans remains limited and inconsistent. Therefore, IGF-1 is not routinely used in standard surgical care, and its use for enhancing post-surgical healing is not broadly validated.

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