Synopsis

Source of validity: Scientific
Rating (out of 5): 4

L-leucine is an essential branched-chain amino acid (BCAA) that plays a critical role in muscle protein synthesis and tissue repair, making it scientifically justified for use in supporting healing after surgery. Multiple studies have demonstrated that leucine stimulates the mammalian target of rapamycin (mTOR) pathway, which is central to the initiation of protein synthesis in muscle and other tissues. This is particularly relevant post-surgery, when muscle breakdown and catabolism are common due to stress, immobility, and inflammation.

Clinical research supports leucine’s benefit as part of nutritional interventions aimed at reducing muscle wasting and promoting recovery after surgery, especially in older adults or those at risk of poor healing. Supplemental leucine, or leucine-enriched protein formulas, have been shown to improve nitrogen balance, muscle mass retention, and wound healing rates in various surgical and critical care populations. For example, a 2012 review in Clinical Nutrition found that BCAA supplementation, particularly leucine, improved postoperative recovery and reduced complications in surgical patients. Guidelines from nutrition societies frequently recommend adequate protein and leucine intake for patients recovering from surgery to optimize healing and functional outcomes.

While more large-scale, high-quality trials are warranted to refine dosage and timing recommendations, current evidence strongly supports the use of leucine as part of a comprehensive nutritional strategy to enhance recovery after surgery.

More about L-leucine
More about Surgery (healing from)

Other ingredients used for Surgery (healing from)

Other health conditions supported by L-leucine

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