Relationship: Surgery (healing from) and protease

Evidence supporting the use of: Protease
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Protease enzymes have been studied for their potential to support healing after surgery, particularly in reducing inflammation, swelling, and pain. The rationale is based on the enzymes’ ability to break down proteins involved in inflammatory processes and tissue debris, theoretically facilitating faster resolution of bruising and edema. Several clinical studies and reviews—particularly on proteolytic enzyme blends such as bromelain, trypsin, and chymotrypsin—have reported positive outcomes in postoperative recovery. For example, a number of trials in dental, orthopedic, and plastic surgery settings have noted decreased postoperative swelling, bruising, and discomfort in patients receiving oral protease supplements compared to placebo. However, while some studies indicate benefits, the overall quality and size of the evidence base are modest, with some studies showing limited or no effect. Systematic reviews have concluded that although there is promising evidence, more rigorous and larger-scale clinical trials are needed to confirm efficacy and to determine optimal dosing and safety parameters. Protease supplementation is generally considered safe when used appropriately, but concerns exist regarding bleeding risk, particularly in patients on anticoagulant therapy. In summary, protease enzymes are used post-surgically based on a growing body of scientific studies suggesting moderate benefit for healing and inflammation reduction, but the strength of evidence is not yet robust enough for universal recommendation. Patients should consult healthcare providers before use, especially when taking other medications.

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Other health conditions supported by protease

Abrasions
Bruises (healing)
Burns and Scalds
Cancer Treatment (reducing side effects)
Congestion (lymphatic)
Cuts
Edema
Exercise
Inflammation
Injuries
Pain (general remedies for)
Scratches and Abrasions
Surgery (healing from)
Tendonitis
Ulcerations (external)
Wounds and Sores

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Evidence supporting the use of: Protease
For the health condition: Surgery (healing from)

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Synopsis

Other ingredients used for Surgery (healing from)

Other health conditions supported by protease

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Health Concerns

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Evidence supporting the use of: ProteaseFor the health condition: Surgery (healing from)

Table of Contents

Synopsis

Other ingredients used for Surgery (healing from)

Other health conditions supported by protease

Products containing protease

Evidence supporting the use of: Protease
For the health condition: Surgery (healing from)