Evidence supporting the use of: Proteoglycans
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proteoglycans are essential macromolecules in the extracellular matrix, playing a key role in tissue structure, hydration, and cellular signaling. Their role in supporting or accelerating healing after surgery has been studied primarily in the context of wound healing, cartilage repair, and tissue engineering. Scientific evidence suggests that proteoglycans, such as decorin, biglycan, and aggrecan, contribute to the modulation of inflammation, regulation of collagen fibrillogenesis, and promotion of tissue remodeling. Animal studies and in vitro experiments indicate that supplementation with proteoglycans or proteoglycan-rich extracts may enhance wound closure rates, improve scar quality, and support cartilage regeneration. However, the majority of these studies are preclinical, and well-designed clinical trials in post-surgical human populations are limited. Some early-stage clinical applications, particularly in orthopedic and dental surgery, have explored proteoglycan-enriched biomaterials and hydrogel scaffolds to support tissue repair. While these findings are promising, the overall level of clinical evidence remains moderate at best, and routine use of proteoglycans as a supplement or treatment for general surgical healing is not yet standard practice. In summary, there is scientific rationale and some experimental support, but more high-quality clinical research is needed to establish efficacy and inform guidelines.

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Products containing Proteoglycans

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