Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Serratiopeptidase is a proteolytic enzyme originally derived from the bacterium Serratia marcescens. It is commonly used in some countries, especially in Asia and Europe, as an adjunct to reduce inflammation, swelling, and pain following surgical procedures. The rationale for its use in post-surgical healing is based on its purported ability to break down inflammatory mediators, fibrin, and dead tissue, thereby promoting faster resolution of edema and hematoma, and improving tissue repair.

Several small clinical trials have evaluated serratiopeptidase for post-surgical swelling and pain. For example, some studies in dental and oral surgery (such as third molar extraction) have shown that serratiopeptidase can reduce swelling and trismus compared to placebo or standard analgesics. However, these studies are often limited by small sample sizes, methodological issues, and lack of rigorous blinding. Meta-analyses and systematic reviews generally conclude that while there is some evidence for benefit, it is weak and inconsistent, and more robust, large-scale randomized controlled trials are needed.

Regulatory bodies in some countries do not recognize serratiopeptidase as a standard treatment for post-surgical recovery, and its safety profile, especially with long-term use, is not fully established. In summary, while there is a scientific basis and some supporting clinical evidence for its use in surgery healing, the overall quality of evidence is low (rated 2/5), and further high-quality research is necessary to confirm its efficacy and safety.

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