Evidence supporting the use of: Serum Protein
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Serum protein, particularly albumin, plays a crucial role in the healing process after surgery. There is strong scientific validation for its use in supporting recovery from surgical procedures. Serum proteins are vital for maintaining oncotic pressure, transporting hormones, vitamins, and drugs, and serving as building blocks for tissue repair. Hypoalbuminemia (low serum albumin levels) is a well-established marker of poor nutritional status and is associated with increased risk of postoperative complications, delayed wound healing, and longer hospital stays.

Clinical studies have demonstrated that patients with adequate serum protein levels—especially those with higher albumin—tend to have better surgical outcomes. In cases where patients are malnourished or have low serum protein levels, supplementation (either via diet or intravenous albumin) can help improve wound healing and reduce the risk of infection.

Guidelines from surgical and critical care societies often recommend assessment and correction of serum protein levels before major surgeries, especially in vulnerable populations (e.g., elderly, patients with chronic illness). While routine albumin supplementation in all surgical patients is not universally recommended, targeted use in those with demonstrated deficits is evidence-based.

References:
- Gibbs J et al., Annals of Surgery, 1999;229(5):595-602.
- Vincent JL et al., Critical Care, 2003;7(2):98-106.
- National Institute for Health and Care Excellence (NICE) Guidelines.

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