Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7,8-Dihydroxyflavone (7,8-DHF) is a synthetic flavonoid that has been studied primarily for its role as a potent and selective agonist of the TrkB receptor, which is the main receptor for brain-derived neurotrophic factor (BDNF). Scientific research in animal models has demonstrated that 7,8-DHF can mimic BDNF activity, leading to neuroprotective, neurogenic, and antidepressant-like effects. While most studies focus on central nervous system (CNS) functions such as memory, mood, and neurodegeneration, there is some evidence that BDNF-TrkB signaling also influences the sympathetic nervous system (SNS). For example, BDNF can enhance sympathetic innervation and activity, and animal studies have shown that manipulating TrkB signaling can affect sympathetic neuron survival and function.

However, the direct use of 7,8-DHF to support the sympathetic nervous system specifically is not well established in clinical research. Most available data derive from preclinical models, and while these suggest potential modulatory effects on SNS pathways, there is limited human evidence. There is no strong tradition of use for this compound, as it is a relatively novel, synthetic molecule. Therefore, while there is a scientific rationale for its investigation in supporting the SNS, the overall strength of evidence is currently weak, meriting a rating of 2 out of 5.

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