Evidence supporting the use of: Acetyl L-Tyrosine
For the body system: Sympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Acetyl L-Tyrosine is a modified form of the amino acid L-tyrosine, which is a precursor for the synthesis of catecholamines such as dopamine, norepinephrine, and epinephrine. These neurotransmitters play critical roles in the sympathetic nervous system (SNS), mediating the "fight or flight" response to stress. Scientific studies have investigated tyrosine supplementation (including the acetylated form, which is thought to have better bioavailability) for its potential to support cognitive and physical performance under stress, particularly in situations that activate the SNS, such as cold exposure, sleep deprivation, and intense exercise.

Several human clinical trials have demonstrated that L-tyrosine supplementation can help mitigate cognitive decline during acute stressors, presumably by supporting catecholamine synthesis when stores are depleted. For example, a review in Military Medicine (2007) and studies published in Brain Research Bulletin and Pharmacology Biochemistry and Behavior found that tyrosine can improve working memory and cognitive performance in stressful environments. However, most research is on L-tyrosine rather than the acetylated form, though both are believed to function similarly as precursors. There is moderate scientific evidence that tyrosine, and by extension acetyl L-tyrosine, supports the SNS under stress, but more studies are needed, particularly with the acetylated form, to confirm these effects and their practical significance.

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