Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Adrenal extract has been traditionally used in naturopathic and alternative medicine to "support" the sympathetic nervous system and combat symptoms of adrenal fatigue, stress, and low energy. The rationale is based on the idea that desiccated or processed animal adrenal glands might provide nutrients or hormones that help bolster human adrenal function, thereby supporting sympathetic nervous system activity (which is largely mediated by adrenal hormones like adrenaline and noradrenaline). However, these uses are rooted in early 20th-century organotherapy practices and anecdotal traditions rather than robust scientific research.

Scientific evidence for adrenal extract's efficacy in supporting the sympathetic nervous system is minimal to nonexistent. Most available studies are outdated, poorly controlled, or do not directly assess its effect on the sympathetic nervous system. Modern regulatory agencies, including the FDA, do not recognize adrenal extract as a treatment for adrenal insufficiency or any sympathetic nervous system disorder, and concerns exist about safety, standardization, and contamination. As such, its use persists primarily due to traditional beliefs rather than validated scientific evidence.

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