Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Beta-caryophyllene (BCP) is a bicyclic sesquiterpene found in many essential oils, including clove, black pepper, and cannabis. It is unique among terpenes because it binds selectively to the cannabinoid receptor type 2 (CB2) in the endocannabinoid system, which has a modulatory effect on various physiological processes, including inflammation and pain. While most research focuses on BCP's anti-inflammatory and analgesic properties, several studies have explored its influence on the autonomic nervous system, including the sympathetic branch.

Animal studies have shown that BCP can modulate stress responses. For example, a 2014 study published in Physiology & Behavior demonstrated that BCP administration reduced anxiety-like behavior and normalized sympathetic activity in mice subjected to chronic stress. This effect is believed to be mediated through CB2 receptor activation, which influences the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic outflow. Additionally, BCP's anti-inflammatory action may indirectly support autonomic balance, as chronic inflammation can promote sympathetic overactivity.

However, human studies directly demonstrating BCP's ability to "support" the sympathetic nervous system are lacking. Most evidence is preclinical, and while mechanisms are plausible, more research—especially clinical trials—is needed. Therefore, the use of beta-caryophyllene for sympathetic nervous system support is scientifically plausible but not robustly validated in humans.

More about beta caryophyllene
More about Sympathetic Nervous System

Other ingredients that support Sympathetic Nervous System

Other body systems supported by beta caryophyllene

Products containing beta caryophyllene