Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Brahmi (Bacopa monnieri) is traditionally used in Ayurvedic medicine as a cognitive and adaptogenic herb. Scientific studies have begun to examine its effects on the nervous system, including the sympathetic nervous system (SNS). The primary focus of research has been on Brahmi’s neuroprotective, anxiolytic, and cognitive-enhancing properties. Some preclinical and limited human studies suggest that Brahmi can modulate the body’s response to stress, which is largely orchestrated by the SNS. For example, Brahmi extracts have been shown in animal models to reduce stress-induced increases in cortisol and improve behavioral responses to stress, potentially by modulating catecholamine levels and influencing SNS activity. Human trials are fewer, but some have reported reductions in anxiety and improvements in attention and memory, which may be partially mediated through effects on the autonomic nervous system, including the SNS. However, direct evidence specifically targeting the SNS (i.e., direct measures of sympathetic nerve activity or neurotransmitter modulation in humans) is limited. Most evidence is indirect, focusing on stress and anxiety outcomes. Therefore, while there is a scientific basis for Brahmi’s use in supporting nervous system health and stress adaptation—functions involving the SNS—high-quality, targeted research on its direct effects on the SNS is still emerging. The evidence is stronger than tradition alone, but not robust, hence the rating of 3 out of 5.

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