Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Catecholamines, a class of compounds that include epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine, are well-established agents in supporting the sympathetic nervous system (SNS). These molecules are endogenous neurotransmitters and hormones that play a central role in the 'fight or flight' response, a hallmark of SNS activation. When released, catecholamines increase heart rate, contractility, and blood pressure, and they also mobilize energy stores—effects mediated through adrenergic receptors widely distributed throughout the body.

Clinically, exogenous catecholamines such as epinephrine and norepinephrine are used in acute care settings to manage conditions like cardiac arrest, anaphylaxis, and severe hypotension. Their mechanism of action is directly related to sympathetic stimulation, making their use both scientifically validated and mechanistically appropriate.

Numerous clinical guidelines and textbooks cite the use of catecholamines in emergencies requiring SNS support. Randomized controlled trials, animal studies, and decades of clinical experience solidify the evidence base. Therefore, catecholamines are not only justified by tradition but are also supported by strong, high-quality scientific evidence for supporting the sympathetic nervous system.

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