DHA-conjugated phosphatidylserine (PS) is a phospholipid that contains docosahexaenoic acid (DHA), an omega-3 fatty acid, as part of its structure. Phosphatidylserine has been studied primarily for its effects on cognitive function and the central nervous system, but there is moderate scientific evidence suggesting a role in modulating the sympathetic nervous system (SNS) as well. Several studies have shown that PS supplementation can attenuate the physiological stress response, particularly by reducing cortisol levels and blunting the increase in sympathetic activity induced by acute stressors such as exercise or mental challenges (Starks et al., 2003; Kingsley et al., 2006).

The mechanism is believed to involve the modulation of hypothalamic-pituitary-adrenal (HPA) axis activity, resulting in reduced sympathetic outflow. DHA, as a component of PS, may enhance membrane fluidity and neuronal signaling, potentially supporting this effect, though most studies focus on PS in general rather than specifically DHA-bound forms. While the evidence is not robust or universally accepted for SNS support—hence a mid-range evidence rating—it does suggest that DHA-conjugated PS may help modulate stress-induced SNS activation, rather than directly stimulating or supporting baseline sympathetic function.

In summary, the use of DHA-conjugated phosphatidylserine to support the sympathetic nervous system is justified by moderate scientific evidence, especially in the context of stress response attenuation.