Oriental Ginseng, also known as Panax ginseng, has a longstanding history in traditional medicine systems such as Traditional Chinese Medicine (TCM), where it has been used to enhance vitality and resilience to stress. In modern research, there is increasing scientific validation for its effects on the sympathetic nervous system (SNS), which governs the body’s 'fight or flight' responses. Several studies suggest that Panax ginseng contains active compounds called ginsenosides, which may modulate the release of catecholamines (such as adrenaline and noradrenaline) and influence SNS activity.

Clinical and preclinical data indicate that ginseng may improve physical performance, reduce fatigue, and support adaptation to stress—effects linked to SNS modulation. For instance, research published in journals like Phytotherapy Research and Journal of Ginseng Research has demonstrated that ginseng supplementation can enhance resistance to stress-induced physiological changes, potentially by regulating HPA axis and sympathetic activity. While some studies yield mixed results, the overall trend supports a role for Panax ginseng in supporting and balancing sympathetic nervous system responses, particularly under conditions of chronic stress or fatigue. However, further large-scale, controlled human studies are needed to fully elucidate its mechanisms and clinical effectiveness.