Evidence supporting the use of: Ginsenosides
For the body system: Sympathetic Nervous System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ginsenosides, the primary active compounds in Panax ginseng, have been studied for their effects on the sympathetic nervous system (SNS). Scientific research suggests that ginsenosides modulate the SNS by influencing neurotransmitter release, catecholamine secretion, and adrenergic receptor activity. Preclinical studies have demonstrated that certain ginsenosides can enhance the release of norepinephrine and dopamine, leading to increased sympathetic outflow and alertness. Additionally, some studies indicate that ginsenosides may modulate the stress response by acting on the hypothalamic-pituitary-adrenal (HPA) axis, indirectly supporting SNS activity during stress adaptation.

Clinical trials in humans are relatively limited but some evidence suggests ginseng supplementation may improve mental performance, reduce fatigue, and enhance the body’s ability to cope with physical and psychological stress — all functions related to the SNS. However, results are mixed and often complicated by variations in ginseng extracts, dosage, and study design. The overall body of evidence supports a moderate role for ginsenosides in supporting the SNS, though more rigorous, standardized human trials are needed to confirm these effects and clarify the mechanisms involved. Thus, while there is scientific basis for the use of ginsenosides to support SNS function, the evidence is not yet strong enough for a higher rating.

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