Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Holy Basil (Ocimum sanctum or Tulsi) is traditionally revered in Ayurvedic medicine as an adaptogen, used to help the body cope with stress. Modern research has begun to provide scientific insights into its effects on the sympathetic nervous system, which is responsible for the body's "fight or flight" response. Several preclinical and limited clinical studies suggest that Holy Basil can modulate stress responses, potentially by reducing levels of corticosterone (a stress hormone) and normalizing physiological parameters altered by stress, such as blood pressure and heart rate. Compounds in Holy Basil, like eugenol and ursolic acid, have shown anxiolytic and anti-stress effects in animal models.

In human trials, Holy Basil extracts have been associated with reduced symptoms of stress, improved mood, and cognitive function, which may indirectly support sympathetic nervous system health by reducing chronic overactivation. However, direct clinical evidence documenting Holy Basil's specific effects on sympathetic nervous system activity (e.g., via heart rate variability or catecholamine levels) is limited, and most studies are small or lack rigorous controls. Overall, while traditional use is strong, and some scientific studies are promising, more robust, large-scale human research is needed to confirm these effects and clarify mechanisms. Thus, the evidence is moderate (3/5).

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