Evidence supporting the use of: Rhodiola crenulata
For the body system: Sympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rhodiola crenulata, a species closely related to Rhodiola rosea, has been used traditionally in Tibetan and Chinese medicine as an adaptogen to help the body resist physical, chemical, and biological stressors. Modern scientific research, though more extensive for R. rosea, has also investigated R. crenulata for its adaptogenic and anti-stress properties. The rationale for its use to support the sympathetic nervous system (SNS)—the part of the autonomic nervous system responsible for the "fight or flight" response—stems from evidence that Rhodiola extracts may modulate stress responses and reduce fatigue.

Several in vitro and animal studies suggest that Rhodiola species can influence catecholamine levels (such as adrenaline and noradrenaline), improve resilience to stress, and modulate the hypothalamic-pituitary-adrenal (HPA) axis, which works closely with the SNS. Human clinical data are limited but promising; some trials (often with R. rosea, but a few with R. crenulata) reported reduced fatigue and improved mental performance under stress, suggesting a potential role in supporting SNS function during acute stress and fatigue.

However, most studies are small, short-term, and sometimes do not distinguish between Rhodiola species. Overall, the scientific evidence specifically for R. crenulata in supporting the sympathetic nervous system is moderate, meriting a score of 3 out of 5, with further research needed for conclusive validation.

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