Rosavin is one of the primary active compounds found in Rhodiola rosea, a traditional adaptogenic herb. Scientific research has explored Rhodiola extracts, which contain rosavin, for their effects on the sympathetic nervous system and stress response. Several studies suggest that Rhodiola may help modulate the body’s stress response, potentially by influencing the hypothalamic-pituitary-adrenal (HPA) axis and neurotransmitters such as norepinephrine, which are closely linked to sympathetic nervous system activity. Some double-blind, placebo-controlled trials in humans have demonstrated that Rhodiola supplementation can reduce fatigue, improve attention, and support mental performance during periods of stress, indirectly supporting sympathetic nervous system function.

However, while these effects are promising, the evidence is not robustly specific to rosavin alone, nor does it fully elucidate the direct mechanisms by which rosavin modulates the sympathetic nervous system. Most studies use whole Rhodiola extracts, making it difficult to isolate rosavin's unique contribution. Nevertheless, preclinical and limited clinical data suggest that Rhodiola (with rosavin as a marker compound) can help the body adapt to physical and mental stress, which is mediated through sympathetic nervous system pathways. More research is needed to confirm these effects and to clarify the precise role of rosavin versus other Rhodiola constituents.