Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Salidroside is a phenylpropanoid glycoside found primarily in Rhodiola rosea, a plant traditionally used in adaptogenic and anti-fatigue remedies. Scientifically, salidroside has been studied for its effects on the central and sympathetic nervous systems. Preclinical studies, including animal and in vitro research, suggest that salidroside may modulate the activity of the sympathetic nervous system by influencing neurotransmitter levels (such as norepinephrine and dopamine), reducing stress-induced sympathetic activation, and exhibiting neuroprotective and anti-fatigue properties. For example, studies have shown that salidroside can reduce stress-induced elevations of plasma catecholamines and improve behavioral outcomes in animal models of stress.

However, direct clinical evidence in humans is limited. Most human studies have examined standardized extracts of Rhodiola rosea rather than isolated salidroside, and outcomes have focused on fatigue, stress, and mood rather than specific measures of sympathetic nervous system activity. Nonetheless, the available evidence suggests that salidroside may support the sympathetic nervous system by modulating stress responses and protecting against stress-induced damage. Thus, the use of salidroside for this purpose is supported by a combination of traditional use of Rhodiola and emerging but not yet definitive scientific evidence, justifying a moderate score for scientific support.

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