Evidence supporting the use of: Theacrine
For the body system: Sympathetic Nervous System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Theacrine is a purine alkaloid structurally similar to caffeine, found primarily in the Camellia assamica var. kucha tea plant. It is used in some dietary supplements to support alertness, energy, and mood, with claims that it stimulates the sympathetic nervous system (SNS) much like caffeine. Scientific studies indicate that theacrine acts as an adenosine receptor antagonist and increases dopamine signaling, mechanisms consistent with SNS stimulation. Several small clinical trials and animal studies suggest theacrine can increase energy and reduce fatigue, though its stimulatory effect is generally milder than caffeine and may not produce the same degree of heart rate or blood pressure elevation.

Evidence for direct, robust SNS activation is limited, and most studies focus on subjective feelings of energy or alertness rather than biomarkers of sympathetic activity. There is some evidence that tolerance develops more slowly to theacrine than to caffeine. Overall, while theacrine’s mechanism and preliminary data provide a scientific rationale for its use in supporting the sympathetic nervous system, the quality and quantity of human research are still limited. Therefore, the strength of evidence is moderate to low, reflected in a rating of 2 out of 5.

More about Theacrine
More about Sympathetic Nervous System

Other body systems supported by Theacrine

Brain
Sympathetic Nervous System

Products containing Theacrine

We currently have no products on Vitabase that contain this ingredient.