Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Yohimbine, an alkaloid derived from the bark of the Pausinystalia yohimbe tree, has been studied for its effects on the sympathetic nervous system (SNS). Its primary mechanism of action involves antagonism of alpha-2 adrenergic receptors, which can increase the release of norepinephrine and, consequently, enhance sympathetic outflow. This pharmacological property underlies its traditional use as an aphrodisiac and as a treatment for erectile dysfunction, as well as its more recent use as a stimulant and fat loss aid.

Scientific evidence confirms that yohimbine does acutely increase sympathetic nervous system activity, as demonstrated by increased heart rate, blood pressure, and catecholamine levels in both animal and human studies. Clinical trials have primarily focused on its effects in sexual dysfunction and, to a lesser extent, weight loss, rather than direct support of the SNS as a "body system." Nonetheless, the documented increase in sympathetic activity is the physiological basis for these applications. However, the use of yohimbine is associated with significant side effects related to SNS activation, including anxiety, hypertension, and tachycardia.

In summary, there is scientific evidence that yohimbine activates and supports the sympathetic nervous system by increasing norepinephrine release. However, this effect is a double-edged sword, as excessive stimulation of the SNS can be harmful. The evidence is moderate (3/5), reflecting both the clear mechanism and the risks involved.

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