Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Agonandra species, particularly Agonandra brasiliensis, have been used in traditional medicine in parts of Central and South America. Historical ethnobotanical reports document its use by indigenous communities as a treatment for various ailments, including syphilis. The use is largely based on anecdotal evidence and traditional knowledge passed down through generations, rather than scientific clinical studies. The bark, leaves, or extracts have been prepared in decoctions or infusions and administered either orally or topically with the aim of alleviating symptoms associated with syphilis or other venereal diseases.

However, there is a lack of rigorous pharmacological or clinical evidence supporting the efficacy of Agonandra in treating syphilis. Peer-reviewed scientific literature provides minimal information on the bioactive compounds in Agonandra species and their potential anti-treponemal (anti-syphilitic) effects. The only available support remains ethnomedicinal records and some preliminary phytochemical investigations, which are insufficient to confirm safety or effectiveness. As such, while Agonandra’s use for syphilis is documented in traditional medicine, there is little scientific validation, and its evidence score is low.

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