Evidence supporting the use of: DHEA
For the body system: Testes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced primarily by the adrenal glands, but also in smaller amounts by the testes in men. It serves as a precursor to both androgens (such as testosterone) and estrogens. The rationale for using DHEA to support testicular or male reproductive health is rooted in its role as an androgen precursor; low DHEA levels have been associated with age-related declines in testosterone production.

However, scientific evidence supporting DHEA supplementation specifically for testicular function or direct support of the testes is limited. Some studies in older men and those with adrenal insufficiency have shown that DHEA supplementation can modestly increase circulating androgen levels, but improvements in testicular function, fertility, or direct testicular health have not been consistently demonstrated. Several clinical trials have failed to show significant increases in serum testosterone levels or improvements in sperm parameters in healthy men or those with infertility.

Most guidelines do not recommend DHEA for male reproductive or testicular health outside of specific medical indications (such as adrenal insufficiency). While DHEA is sometimes marketed for "male vitality" or "testosterone support," the evidence base is weak and does not strongly support its efficacy. Therefore, while there is a scientific rationale for its use, current research provides only modest evidence at best for benefits to the testes specifically.

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