Evidence supporting the use of: Eurycomanone
For the body system: Testes

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eurycomanone is a quassinoid compound found in the roots of Eurycoma longifolia, commonly known as Tongkat Ali. The use of Tongkat Ali roots to support male reproductive health, including testicular function, is well established in traditional Southeast Asian medicine. In recent years, scientific research has begun to validate some of these traditional claims. Eurycomanone has been identified as one of the main bioactive constituents responsible for these effects.

Preclinical studies (mainly in rodents) have shown that Eurycomanone may stimulate testosterone production by activating the hypothalamic-pituitary-gonadal axis and increasing the release of luteinizing hormone, which in turn stimulates Leydig cells in the testes to produce testosterone. Several animal studies demonstrate increased serum testosterone levels and improved spermatogenesis after administration of Eurycomanone or Tongkat Ali extracts standardized for Eurycomanone content. Limited human clinical trials with Tongkat Ali extracts (not pure Eurycomanone) report modest increases in testosterone and improvements in semen quality, though these studies are often small and sometimes lack rigorous controls. The direct effects of isolated Eurycomanone in humans remain underexplored.

Overall, while there is a scientific basis for the use of Eurycomanone-containing extracts to support testicular function and male reproductive health, the evidence is stronger in animal models than in human clinical trials. Thus, the evidence rating is moderate (3/5), reflecting promising but not conclusive support.

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