Evidence supporting the use of: 3-hydroxy-5alpha-androst-1-en-17-one
For the body system: Testosterone

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

3-hydroxy-5alpha-androst-1-en-17-one, also known as 1-Androsterone or 1-Andro, is a synthetic derivative of the hormone DHEA (dehydroepiandrosterone). It is classified as a "prohormone" because it can be converted in the body into 1-testosterone (1-test), a non-aromatizing anabolic steroid. The rationale for its use to support the testosterone body system is based primarily on its metabolic conversion to anabolic and androgenic compounds, which may mimic some effects of endogenous testosterone, such as increased muscle mass, strength, and possibly libido.

There is limited direct scientific research on 3-hydroxy-5alpha-androst-1-en-17-one in humans. Most available evidence comes from animal studies or extrapolation from the known effects of related compounds. Some in vitro and animal data suggest that 1-testosterone, its active metabolite, binds the androgen receptor and exerts anabolic effects. However, well-designed clinical trials in humans are lacking, and safety data are minimal. Regulatory agencies have classified related compounds as anabolic steroids, and their use can disrupt natural hormone balance.

In summary, while there is a plausible biochemical mechanism for 3-hydroxy-5alpha-androst-1-en-17-one to influence the testosterone body system, the direct scientific evidence supporting its efficacy in humans is weak and mostly theoretical. The evidence rating is therefore low (2/5), reflecting the gap between mechanistic plausibility and demonstrated clinical benefit.

More about 3-hydroxy-5alpha-androst-1-en-17-one
More about Testosterone

Other body systems supported by 3-hydroxy-5alpha-androst-1-en-17-one

Testosterone

Products containing 3-hydroxy-5alpha-androst-1-en-17-one

We currently have no products on Vitabase that contain this ingredient.