Evidence supporting the use of: 4-DHEA
For the body system: Testosterone

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

4-DHEA (4-Dehydroepiandrosterone) is a synthetic prohormone that is structurally related to DHEA, a naturally occurring hormone in the human body. 4-DHEA can be converted in the body to testosterone or other androgens through enzymatic processes. Its use as a testosterone support supplement is primarily based on its status as a prohormone, with the rationale that increasing precursor hormones may raise endogenous testosterone production. There is some scientific basis for this mechanism, as studies have shown that certain prohormones can elevate testosterone levels when metabolized. However, direct clinical evidence on 4-DHEA’s effectiveness in increasing testosterone specifically and safely in humans is extremely limited. Most of the data comes from in vitro studies, animal models, or extrapolation from related compounds such as DHEA or androstenedione. Safety, efficacy, and long-term effects have not been thoroughly studied in well-controlled human trials. Furthermore, prohormones like 4-DHEA are often associated with potential side effects and are banned in many sports organizations. In summary, while there is some mechanistic scientific rationale for 4-DHEA's use to support testosterone, the direct clinical evidence is weak, resulting in a low evidence rating.

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Other body systems supported by 4-DHEA

Testosterone

Products containing 4-DHEA

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