Evidence supporting the use of: DHEA
For the body system: Testosterone

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced by the adrenal glands. It serves as a precursor to both androgens (including testosterone) and estrogens. The rationale for using DHEA to support the "Testosterone body system" is based on its biochemical role in the steroidogenesis pathway, where it can be converted into testosterone in peripheral tissues. Scientific studies in older adults and certain clinical populations (such as those with adrenal insufficiency) have shown that DHEA supplementation can modestly increase serum testosterone levels, particularly in women and older men whose endogenous DHEA production has declined with age. However, the magnitude of these increases is generally small and the clinical significance remains uncertain.

A 2013 meta-analysis in Clinical Endocrinology found that DHEA supplementation produced small increases in testosterone in women, but effects in men were less consistent. The Endocrine Society does not currently recommend DHEA supplementation for the general population due to limited evidence of meaningful clinical benefits and potential side effects. In summary, while DHEA is used with the intent to support testosterone levels and there is some scientific basis for its use as a testosterone precursor, the overall strength of evidence is modest (rated 2/5). Its use is better supported in specific clinical situations rather than for broad enhancement of testosterone in healthy individuals.

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