Evidence supporting the use of: Icariin
For the body system: Testosterone

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Icariin, a flavonoid compound derived from the Epimedium species (commonly known as Horny Goat Weed), has a long history of use in traditional Chinese medicine for enhancing male vitality and sexual function. In recent years, scientific research has explored its potential role in supporting the testosterone system. Animal studies suggest that icariin may increase serum testosterone levels, possibly by stimulating the production of luteinizing hormone or by modulating enzymes involved in steroidogenesis. For example, studies in rats have shown increased testosterone and improved reproductive organ weights following icariin administration. In vitro experiments also indicate that icariin may inhibit phosphodiesterase type 5 (PDE5), which can support erectile function and potentially influence testosterone indirectly.

However, despite these promising preclinical findings, robust clinical evidence in humans is limited. Few human trials directly assess the effect of icariin on testosterone levels or related outcomes. Most human studies are small, short-term, or focus primarily on sexual function rather than hormonal changes. Therefore, while there is a scientific basis for the use of icariin to support testosterone—mainly from animal and laboratory studies—the overall evidence is weak and not yet conclusive. Further well-designed clinical trials are needed to confirm its efficacy and safety in humans.

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