Evidence supporting the use of: Lipids (unspecified)
For the body system: Testosterone

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lipids, particularly cholesterol, play a scientifically validated role in testosterone production. Testosterone is a steroid hormone synthesized from cholesterol in the Leydig cells of the testes. The biosynthesis pathway involves the conversion of cholesterol into pregnenolone, which is then further processed into testosterone. Numerous biochemical and physiological studies have demonstrated that inadequate lipid (and specifically cholesterol) intake can impair steroidogenesis, leading to reduced testosterone levels. For example, clinical and animal studies have shown that low-fat diets can lead to decreased testosterone concentrations, while adequate or slightly higher fat intake (including saturated and monounsaturated fats) is associated with healthier testosterone levels in men. However, not all lipids are equal in this context; polyunsaturated fats, especially in excess, may have a neutral or even negative effect on testosterone. While there is no evidence for the use of generic "unspecified" lipids as a supplement, the physiological necessity of certain lipids for sex hormone synthesis is well-established. Thus, ensuring adequate lipid intake is important for hormonal health, including testosterone production, but supplementation with "lipids (unspecified)" is not a standard practice, and the evidence does not support excessive or indiscriminate lipid consumption for this purpose.

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