Evidence supporting the use of: Ginsenoside
For the health condition: Testosterone (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginsenosides are the primary active compounds found in Panax ginseng, a herb traditionally used in East Asian medicine. There is some scientific evidence suggesting that ginsenosides may influence testosterone levels, although the quality and consistency of the evidence are limited. Several animal studies have reported that ginsenosides can increase serum testosterone levels, potentially by stimulating the hypothalamic-pituitary-gonadal axis or by providing antioxidant protection to Leydig cells, which produce testosterone. A few small-scale human studies have examined ginseng supplementation and observed modest increases in testosterone, but results are not consistent across all trials. The mechanisms proposed include improved blood flow and reduction in oxidative stress, which may indirectly support testosterone production. However, the number of well-designed, large-scale human clinical trials is limited, and some studies have failed to show significant effects on testosterone. Overall, while there is a plausible biological mechanism and some preliminary supportive data, the evidence is not robust. Therefore, ginsenosides are used for supporting testosterone based more on early scientific findings than on strong clinical proof. More research, particularly larger and better-controlled human studies, is needed to establish efficacy and dosage guidelines for this indication.

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