Evidence supporting the use of: Immunoglobulins
For the health condition: Tetanus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Immunoglobulins, specifically human tetanus immune globulin (TIG), are scientifically validated for the treatment and support of tetanus. Tetanus is caused by the neurotoxin tetanospasmin, produced by Clostridium tetani. The toxin binds irreversibly to nerve endings, leading to muscle rigidity and spasms. The primary rationale for administering TIG is that it provides passive immunity by supplying pre-formed anti-tetanus antibodies, which neutralize free, circulating toxin that has not yet bound to nerve tissue. This mechanism is well-supported by both experimental and clinical data.

Numerous clinical guidelines, including those from the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), recommend TIG as part of the standard treatment for tetanus. Studies have shown that administration of TIG reduces mortality and morbidity when given promptly. It is important to note, however, that TIG cannot reverse the effects of toxin already bound to nerve tissue, which is why early administration is critical.

The use of immunoglobulins for tetanus is not based on tradition alone, but on substantial scientific evidence accumulated over many decades, including controlled studies and extensive clinical experience. TIG is also used for post-exposure prophylaxis in individuals with uncertain or incomplete immunization histories. Its efficacy and safety profile are well established, making it a cornerstone of tetanus management.

More about Immunoglobulins
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Other ingredients used for Tetanus

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Products containing Immunoglobulins

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