Evidence supporting the use of: Aniracetam
For the health condition: Thinking (cloudy)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aniracetam is a synthetic nootropic compound in the racetam family, developed in the 1970s. It has been studied primarily for its potential cognitive-enhancing effects, including improvement in memory, learning, and symptoms related to "cloudy thinking" or cognitive impairment. Most scientific evidence comes from animal research and a limited number of small-scale human studies, often focusing on populations with cognitive decline or dementia.

Clinical trials in humans are relatively few and often have methodological limitations. Some studies suggest that Aniracetam may improve aspects of cognition, such as memory and attention, particularly in elderly individuals with mild cognitive impairment or early dementia. The proposed mechanisms include modulation of AMPA receptors (a subtype of glutamate receptor involved in synaptic transmission and plasticity), enhancement of cholinergic neurotransmission, and possible anti-anxiety effects. Some users report subjective improvements in mental clarity and reduced "brain fog," but these claims are not robustly supported by large, well-controlled clinical trials in healthy individuals.

Overall, while there is some scientific rationale and preliminary evidence supporting the use of Aniracetam for cognitive symptoms like "cloudy thinking," the quality and quantity of evidence are limited. The evidence for its use in healthy individuals seeking cognitive enhancement is especially weak. Regulatory agencies have not approved Aniracetam for medical use outside certain countries, and its safety profile for long-term use is not fully established.

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