Evidence supporting the use of: Methylliberine
For the health condition: Thinking (cloudy)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Methylliberine, also known as Dynamine®, is a purine alkaloid structurally similar to caffeine and theacrine. Its use for supporting cognitive function—including mitigating “cloudy thinking” or “brain fog”—is based largely on its purported stimulant effects. Preliminary research indicates that methylliberine may increase energy, alertness, and focus, but high-quality human studies remain extremely limited. A small number of open-label and animal studies suggest methylliberine may enhance subjective perceptions of alertness and cognitive performance, likely by modulating adenosine receptors and neurotransmitters much like caffeine. However, these studies are either small, unpublished, or not peer-reviewed, and the cognitive effects in humans have not been robustly characterized. Reviews or summary statements from ingredient suppliers often extrapolate benefits from the established effects of caffeine and theacrine, but direct evidence of methylliberine’s efficacy for cognitive symptoms like “cloudy thinking” is lacking. Thus, while there is a plausible mechanism and some preliminary support, the evidence base is currently weak and insufficient to draw firm conclusions. More rigorous, placebo-controlled clinical trials in humans are needed to validate its effectiveness for this purpose.

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Products containing Methylliberine

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