Evidence supporting the use of: Selenocysteine
For the body system: Thyroid Gland

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Selenocysteine is a key amino acid that serves as the active site in several selenoproteins, including the glutathione peroxidases and the iodothyronine deiodinases, which are crucial enzymes for thyroid hormone metabolism. The thyroid gland contains more selenium per gram of tissue than most other organs in the body, emphasizing its importance for thyroid health. Selenocysteine-containing deiodinases are responsible for the activation and deactivation of thyroid hormones (conversion of thyroxine/T4 to the more active form, triiodothyronine/T3). Scientific studies, including randomized controlled trials and observational studies, have shown that selenium supplementation can benefit individuals with certain thyroid disorders, such as autoimmune thyroiditis (Hashimoto’s thyroiditis) and Graves’ disease, by modulating immune responses and decreasing thyroid-specific autoantibodies. However, evidence for selenium supplementation improving thyroid function in healthy populations is less robust, and excessive supplementation can be harmful. Overall, the use of selenocysteine (or selenium) in supporting thyroid health is strongly supported by scientific literature, particularly in the context of selenium deficiency or autoimmune thyroid disease. Notably, most dietary selenium is incorporated into selenoproteins as selenocysteine, which underscores its biological relevance.

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Products containing Selenocysteine

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