Evidence supporting the use of: Melatonin
For the health condition: Tinnitus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin has been investigated for its potential role in the management of tinnitus, primarily due to its effects on sleep and its antioxidant properties. Several clinical studies, including randomized controlled trials, have evaluated melatonin supplementation in patients with tinnitus. The rationale is that tinnitus often disrupts sleep, and poor sleep can exacerbate the perception of tinnitus, creating a negative feedback loop. Melatonin, being a regulator of circadian rhythm and sleep quality, may help break this cycle by improving sleep in affected individuals.

Some studies have shown that melatonin can reduce the severity of tinnitus symptoms, especially in patients who also suffer from insomnia. For example, a double-blind, placebo-controlled study published in Otolaryngology–Head and Neck Surgery (2006) found that melatonin improved tinnitus severity and sleep quality in adults. However, these benefits are modest, and not all studies have found significant improvements.

The precise mechanism by which melatonin might influence tinnitus is not fully understood, but it is postulated to involve both its sleep-promoting effects and its antioxidant action, which may protect auditory pathways from oxidative stress. Despite some positive findings, the overall quality of evidence remains moderate to low, and larger, well-designed studies are needed to confirm efficacy.

In summary, there is some scientific evidence, mostly related to sleep improvement, supporting the use of melatonin in tinnitus patients, but it is not considered a definitive treatment. Its use may be justified in patients who have both tinnitus and sleep disturbances.

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