Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactoperoxidase is an enzyme naturally present in saliva that plays a role in the oral antimicrobial defense system. Its use to support or treat tooth decay (dental caries) is primarily justified by scientific evidence, though the strength of the evidence is moderate. The lactoperoxidase system, when combined with other components such as thiocyanate and hydrogen peroxide, generates hypothiocyanite ions, which have been shown to inhibit the growth of cariogenic bacteria such as Streptococcus mutans. These bacteria are implicated in the development of dental caries due to their acid production from carbohydrate metabolism.

Several in vitro and clinical studies have examined the effect of lactoperoxidase-containing oral care products, such as toothpaste and mouth rinses. Research has shown that these products can reduce bacterial counts in the mouth and may help maintain a healthy oral microbiome. Some randomized controlled trials have suggested a reduction in plaque accumulation and a potential decrease in caries risk, especially in individuals with reduced salivary flow (such as those with xerostomia).

However, while the mechanism of action is well understood and the antibacterial effect is consistently demonstrated, direct evidence for significant reductions in dental caries incidence in the general population is less robust. Further large-scale, long-term clinical trials are needed to definitively establish the caries-preventive effect of lactoperoxidase. Nonetheless, its inclusion in oral hygiene products is supported by moderate scientific validation.

More about Lactoperoxidase
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Other ingredients used for Tooth Decay

Other health conditions supported by Lactoperoxidase

Products containing Lactoperoxidase

Metagenics Probioplex® Intensive Care Powder