Evidence supporting the use of: Nitrous Oxide
For the health condition: Toothache

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Nitrous oxide, commonly known as "laughing gas," is scientifically validated for use in the management of toothache, particularly in dental procedures. Its primary function is not to treat the underlying cause of toothache but to provide analgesia (pain relief) and anxiolysis (anxiety reduction) during dental interventions. Nitrous oxide has been used in dentistry since the mid-19th century, following its discovery by Humphry Davy in the late 18th century and its subsequent promotion by Horace Wells in the 1840s as a dental anesthetic.

Numerous clinical studies and systematic reviews have demonstrated that nitrous oxide, administered via inhalation, is effective and safe for conscious sedation in both adult and pediatric dental patients. It rapidly induces a state of mild euphoria, reduces pain perception, and diminishes anxiety, making dental procedures—including those addressing toothache—more tolerable. The analgesic effects are reversible, and recovery is quick, which is another reason for its widespread use in dental practice.

Major dental and medical organizations, including the American Dental Association and the American Academy of Pediatric Dentistry, endorse nitrous oxide for procedural pain and anxiety management. In summary, nitrous oxide's use in supporting toothache is scientifically justified, with robust evidence supporting its efficacy and safety as a short-term analgesic and anxiolytic agent in dental care.

More about Nitrous Oxide
More about Toothache

Other ingredients used for Toothache

allspice
aloe vera
betel
camphor oil
Alpha-terpineol
Poppy

Products containing Nitrous Oxide

We currently have no products on Vitabase that contain this ingredient.