Synopsis

Source of validity: Scientific
Rating (out of 5): 2

β-Nicotinamide mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a key coenzyme involved in cellular metabolism and energy production. Recently, NMN has gained attention for its potential metabolic benefits, including effects on lipid metabolism. Some preclinical (animal) studies suggest that NMN supplementation may help improve lipid profiles by enhancing mitochondrial function and modulating pathways involved in fat metabolism. For instance, research in mice has shown that NMN administration can reduce hepatic triglyceride accumulation and improve insulin sensitivity, both of which are linked to lower blood triglyceride levels. The proposed mechanisms include activation of sirtuins (SIRT1), increased NAD+ availability, and improved mitochondrial oxidative capacity, all of which may contribute to more efficient fat metabolism and reduced hypertriglyceridemia.

However, clinical evidence in humans is still sparse and largely preliminary. A few small pilot studies have examined NMN’s impact on metabolic parameters in humans, but robust data specifically demonstrating a significant reduction in triglyceride levels are lacking. Most human trials to date focus on safety, NAD+ levels, and glucose metabolism, with lipid effects reported as secondary or exploratory outcomes. Thus, while there is a plausible biological rationale and encouraging animal data, current scientific support for using NMN to treat or support high triglycerides is limited. Larger, well-controlled human studies are needed to establish efficacy and determine appropriate dosing. Therefore, NMN’s use for hypertriglyceridemia is best described as “emerging” but not yet strongly validated.

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Products containing β-nicotinamide mononucleotide (NMN)

Designs For Health Liposomal NMN Synergy 1.7 fl oz (50 ml) liquid. Nonreturnable item.