Synopsis

Source of validity: Scientific
Rating (out of 5): 2

4-Hydroxyisoleucine is a non-proteinogenic amino acid found primarily in fenugreek seeds (Trigonella foenum-graecum). There is some scientific evidence suggesting that 4-hydroxyisoleucine may have beneficial effects on lipid metabolism, including triglyceride levels, primarily through its insulinotropic and hypolipidemic actions. Several animal studies and a few small human trials have explored these effects. In animal models of diabetes and hyperlipidemia, supplementation with 4-hydroxyisoleucine has been shown to reduce plasma triglycerides and cholesterol, possibly by improving insulin sensitivity and modulating lipid synthesis pathways in the liver.

Human data are limited but promising: a small randomized controlled trial in patients with type 2 diabetes reported that fenugreek seed extract enriched in 4-hydroxyisoleucine led to modest reductions in triglyceride levels compared to placebo. The proposed mechanisms include enhanced insulin secretion, increased peripheral glucose uptake, and decreased hepatic lipogenesis, which together may contribute to lower circulating triglyceride concentrations.

However, the overall quality and quantity of evidence is still low, with most studies being preclinical or involving small sample sizes. Larger, well-controlled human trials are needed to confirm efficacy and safety. Thus, the scientific evidence supporting the use of 4-hydroxyisoleucine for high triglycerides exists but is preliminary and not yet robust.

More about 4-hydroxyisoleucine
More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-hydroxyisoleucine
Adzuki bean
Akkermansia muciniphila
algal oil
Algal protein
Algalin
Alliin
Almond fruit
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
anthocyanins
apple
arabinoxylan
argan nut oil
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
ashwagandha
astaxanthin
astragaloside
avocado
banaba
beet
berberine
bergamot
beta-glucan
black currant
black garlic
black ginger
black tea
blueberry
bottle gourd
Brassica
Brazil nut
broccoli
brutieridin
Buckwheat
Buglossoides arvensis
calamari oil
Calanus finmarchicus
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camelina oil
capsiate
cardarine
carnosic acid
cashew
catechins
chia seed
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Chitin-Glucan Complex
chitosan
chlorogenic acid
chokeberry
choline
cocoa
cod liver oil
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conjugated linoleic acid (CLA)
cordyceps
coriander
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cyanidin
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daidzein
daidzin
danshen
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
diosgenin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Echium
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eicosapentaenoic acid
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emblicanin
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eriocitrin
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flavanols
flavanones
flaxseed
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fucosterol
fucoxanthin
genistein
genistin
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goji berry
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green tea
guar gum
guggul
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vitamin C
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β-nicotinamide mononucleotide (NMN)

Other health conditions supported by 4-hydroxyisoleucine

Diabetes
Fatty Liver Disease
Metabolic Syndrome
Triglycerides (high)

Products containing 4-hydroxyisoleucine

We currently have no products on Vitabase that contain this ingredient.