Evidence supporting the use of: Ampelopsin
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ampelopsin, also known as dihydromyricetin (DHM), is a flavonoid compound found in plants such as Ampelopsis grossedentata. There is some emerging scientific evidence suggesting that Ampelopsin may influence lipid metabolism, including the regulation of triglyceride levels. Preclinical studies—primarily in animal models—have shown that Ampelopsin supplementation can reduce serum triglyceride concentrations. For example, several rodent studies have reported decreased triglyceride, total cholesterol, and LDL cholesterol levels after administration of DHM, potentially by modulating lipid synthesis pathways, upregulating fatty acid oxidation, and improving insulin sensitivity. The proposed mechanisms involve AMP-activated protein kinase (AMPK) activation and antioxidant effects that may protect against diet-induced dyslipidemia. However, human clinical data are very limited; there are few, if any, well-powered randomized controlled trials directly evaluating Ampelopsin’s effect on triglycerides in humans. Most available evidence is preclinical, and while promising, cannot be directly extrapolated to clinical practice without further confirmation. Thus, while there is scientific interest and some experimental support, the evidence is currently insufficient for strong clinical recommendations, and the rating reflects both the promise of preclinical data and the lack of robust human trials.

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4-hydroxyisoleucine
Adzuki bean
Akkermansia muciniphila
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Products containing ampelopsin

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