Evidence supporting the use of: Carnosic acid
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Carnosic acid, a polyphenolic diterpene found primarily in rosemary (Rosmarinus officinalis), has been investigated for its potential lipid-lowering effects, including its impact on triglyceride levels. The scientific evidence supporting its use for treating high triglycerides comes primarily from preclinical studies. Several animal studies have demonstrated that carnosic acid and rosemary extracts can decrease serum triglyceride levels, possibly through mechanisms involving the modulation of lipid metabolism, inhibition of lipogenesis, and enhancement of fatty acid oxidation. For instance, research using high-fat diet-induced hyperlipidemic rodent models has shown reductions in triglycerides and improvements in overall lipid profiles following supplementation with carnosic acid or rosemary extract. Additionally, in vitro studies indicate that carnosic acid may activate AMP-activated protein kinase (AMPK), a key regulator of lipid metabolism. However, there is a lack of large-scale, high-quality clinical trials in humans directly assessing the efficacy of carnosic acid for lowering triglycerides. Most available evidence is limited to animal models and cell culture studies, with only a few small human studies using rosemary extracts (not isolated carnosic acid) suggesting possible lipid-lowering effects. As such, while the mechanistic rationale and preclinical data are promising, the evidence base is not strong or definitive. Therefore, the overall scientific support for carnosic acid in treating high triglycerides is limited, meriting a rating of 2 out of 5.

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Products containing carnosic acid

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