Evidence supporting the use of: Conjugated linoleic acid (CLA)
For the health condition: Triglycerides (high)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Conjugated linoleic acid (CLA) is a group of fatty acid isomers found naturally in meat and dairy products. Its supplementation has been investigated for potential health benefits, including effects on lipid metabolism and triglyceride levels. Several animal studies have suggested that CLA may reduce triglyceride concentrations by modulating lipid metabolism and gene expression related to fat synthesis and breakdown. However, the translation of these effects to humans has been inconsistent and modest at best.

Clinical studies in humans provide mixed results. Some randomized controlled trials show a small reduction in serum triglycerides with CLA supplementation, while others report no significant effect. A 2015 meta-analysis of randomized controlled trials in humans concluded that CLA supplementation produces only a minor, statistically insignificant effect on triglyceride levels. The doses used in these studies typically range from 2 to 6 grams per day over periods of 6 to 24 weeks.

The proposed mechanisms include enhanced fatty acid oxidation and reduced fat synthesis, but evidence for substantial clinical benefit in lowering triglycerides remains limited. CLA is not widely recommended by medical guidelines for the management of high triglycerides.

In summary, although there is scientific interest and some mechanistic plausibility, current human evidence does not strongly support the use of CLA for significantly lowering elevated triglycerides. The overall quality and consistency of evidence rates as low to moderate.

More about conjugated linoleic acid (CLA)
More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
anchovies
anthocyanins
apple
arjun tree
artichoke
ashwagandha
astaxanthin
banaba
beet
berberine
bergamot
Beta-Glucan
black currant
black garlic
sesame
black tea
blueberry
broccoli
calamari oil
canola oil
catechins
chia seed
chokeberry
choline
coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
daidzin
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
flaxseed
fruit and vegetable blend (proprietary)
genistein
genistin
glucomannan
grape
grapefruit
green tea
guar gum
guggul
hawthorn
hesperetin
hibiscus
inulin
knotweed
kale
krill oil
kudzu
l-carnitine
l-taurine
lecithin
lignans
linoleic acid (LA)
lycopene
mackerel
magnesium
maqui berry
matcha
naringin
niacin (vitamin B3)
oat
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
pantethine
perilla
phospholipids
pine bark
plant sterols
pomegranate
pomelo
quercetin
quinoa
red yeast rice
resveratrol
safflower oil
sardines
silymarin
black ginger
soybean
spirulina
sterols
stevia
strawberry
tocotrienols
tomato
trans-pterostilbene
trimethylglycine (TMG)
almond fruit
ubiquinol
vegetable and fruit blend (proprietary)
vitamin C
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
lingzhi
sunflower
yerba mate
goji berry
amaranth
kidney beans
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-hydroxyisoleucine
Arjuna
Aronia melanocarpa
Avocado
Ascophyllum nodosum
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Alpha phytosterol
Algal protein
Arjunic Acid
Algalin
Alliin
Arabinoxylan
Argan nut oil
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Buglossoides arvensis
Brutieridin
Brassica
Brazil nut
Buckwheat
Bottle gourd
California chia
Cardarine
Chitosan
Camelina Oil
Cod Liver Oil
Coriander
Cashew
Cyanidin
chlorogenic acid
Chinese Fleeceflower
Cynarin
Cruciferous
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Danshen
Daidzein
Dragon Fruit
Diosgenin
Eriocitrin
Emblicanin
Eicosatetraenoic acid
Eicosapentaenoic Acid
Echium
Ecklonia
Flammulina velutipes
Isoflavones
Pistachio
Soy Protein
walnut