Relationship: Triglycerides (high) and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Docosahexaenoic acid (DHA) is an omega-3 fatty acid found in fish oil and marine sources. Its use to support or treat high triglyceride levels is scientifically validated. Multiple randomized controlled trials and meta-analyses have demonstrated that DHA, often in combination with eicosapentaenoic acid (EPA), can significantly reduce serum triglyceride levels. The mechanism is thought to involve decreased hepatic very-low-density lipoprotein (VLDL) synthesis and secretion, increased beta-oxidation of fatty acids, and enhanced clearance of triglyceride-rich particles from plasma.

Clinical guidelines recognize omega-3 fatty acids (including DHA) as an adjunct treatment for hypertriglyceridemia, particularly for individuals with triglyceride levels above 500 mg/dL. Prescription formulations, such as icosapent ethyl and omega-3-acid ethyl esters, contain concentrated EPA and DHA and are approved for this purpose. While both EPA and DHA lower triglycerides, DHA may increase LDL cholesterol in some individuals, whereas EPA does not; however, the net effect is a reduction in cardiovascular risk factors.

In summary, there is robust human clinical trial evidence supporting the use of DHA for lowering triglycerides, and its use is endorsed by organizations such as the American Heart Association. The evidence base justifies a rating of 4 out of 5 due to consistent findings, though not all studies use DHA alone, and long-term cardiovascular outcome data are still being evaluated.

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Other ingredients used for Triglycerides (high)

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calamari oil
canola oil
catechins
chia seed
chokeberry
choline
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conjugated linoleic acid (CLA)
cordyceps
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DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
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Products containing DHA (docosahexaeonic acid)

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Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaeonic acid)For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Triglycerides (high)