Relationship: Triglycerides (high) and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Docosahexaenoic acid (DHA) is an omega-3 fatty acid found in fish oil and marine sources. Its use to support or treat high triglyceride levels is scientifically validated. Multiple randomized controlled trials and meta-analyses have demonstrated that DHA, often in combination with eicosapentaenoic acid (EPA), can significantly reduce serum triglyceride levels. The mechanism is thought to involve decreased hepatic very-low-density lipoprotein (VLDL) synthesis and secretion, increased beta-oxidation of fatty acids, and enhanced clearance of triglyceride-rich particles from plasma.

Clinical guidelines recognize omega-3 fatty acids (including DHA) as an adjunct treatment for hypertriglyceridemia, particularly for individuals with triglyceride levels above 500 mg/dL. Prescription formulations, such as icosapent ethyl and omega-3-acid ethyl esters, contain concentrated EPA and DHA and are approved for this purpose. While both EPA and DHA lower triglycerides, DHA may increase LDL cholesterol in some individuals, whereas EPA does not; however, the net effect is a reduction in cardiovascular risk factors.

In summary, there is robust human clinical trial evidence supporting the use of DHA for lowering triglycerides, and its use is endorsed by organizations such as the American Heart Association. The evidence base justifies a rating of 4 out of 5 due to consistent findings, though not all studies use DHA alone, and long-term cardiovascular outcome data are still being evaluated.

More about DHA (docosahexaenoic acid)
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Other ingredients used for Triglycerides (high)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-hydroxyisoleucine
Adzuki bean
Akkermansia muciniphila
algal oil
Algal protein
Algalin
Alliin
Almond fruit
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
anthocyanins
apple
arabinoxylan
argan nut oil
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
ashwagandha
astaxanthin
astragaloside
avocado
banaba
beet
berberine
bergamot
beta-glucan
black currant
black garlic
black ginger
black tea
blueberry
bottle gourd
Brassica
Brazil nut
broccoli
brutieridin
Buckwheat
Buglossoides arvensis
calamari oil
Calanus finmarchicus
California chia
camelina oil
capsiate
cardarine
carnosic acid
cashew
catechins
chia seed
Chinese fleeceflower
Chitin-Glucan Complex
chitosan
chlorogenic acid
chokeberry
choline
cocoa
cod liver oil
Coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
coriander
corosolic acid
crocetin
cruciferous
Crypthecodinium
cyanidin
cynarin
daidzein
daidzin
danshen
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
diosgenin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Echium
Ecklonia
eicosapentaenoic acid
Eicosatetraenoic acid
emblicanin
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
eriocitrin
fish
fish protein
Flammulina velutipes
flavanols
flavanones
flaxseed
fo-ti
fruit and vegetable blend (proprietary)
fucosterol
fucoxanthin
genistein
genistin
Ginsenosides
glucomannan
Glucoraphanin
goji berry
grape
grapefruit
green tea
guar gum
guggul
Guggulsterones
Gypenoside
hawthorn
hesperetin
hibiscus
horse gram
hydroxycinnamic acid
hydroxytyrosol
inulin
Irvingia gabonensis
isoflavones
jiaogulan
Jicama
Kaempferide
Kaempferol
kale
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kidney beans
kiwi
knotweed
Konjac
krill oil
kuding tea
kudzu
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l-carnitine
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lecithin
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lignans
lingzhi
linoleic acid (LA)
linseed oil
lupin
lycopene
macadamia
magnesium
mangiferin
maqui berry
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Maslinic acid
Matcha
Mate
Millet
Monacolin
Monounsaturated fat
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Myricetin
Nannochloropsis
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Naringin
Niacin (vitamin B3)
Nobiletin
oat
oleanolic acid
oleic acid
Oleuropein
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oolong tea
Osthole
oyster mushroom
palmitoleic acid
pantethine
perilla
Phaeophyceae
phospholipids
Phytoestrogens
Piceid
pine bark
Pinolenic acid
Pistachio
Plankton
plant sterols
Pleurotus eryngii
Plukenetia volubilis
polychitosamine
Polydatin
polymethoxylated flavones
polyunsaturated fat
pomegranate
pomelo
pu-er tea
Puerarin
punicalagins
purple tea
quercetin
quinoa
rapeseed oil
red yeast
red yeast rice
resveratrol
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S-allylcysteine
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safflower oil
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Salidroside
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Salvianolic acid
Schisandrins
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sesame
Sesamin
Sesamolin
Shilajit
Silybin
silymarin
Sitosterol
Soy
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soybean
spirulina
Stearidonic acid
sterols
Stilbenoid
strawberry
sunflower
Tagatose
Tangeretin
Tanshinone
Taurine
Taxifolin
Tejocote
Tetradecylthioacetic acid
Theabrownin
Theaflavin
Thylakoid
tocotrienols
Trans-pterostilbene
Trimethylglycine (TMG)
ubiquinol
Ursolic Acid
vegetable and fruit blend (proprietary)
vegetable oil
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vitamin C
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Products containing DHA (docosahexaenoic acid)

Health Concerns

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Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaenoic acid)For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Triglycerides (high)