Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diallyl trisulfide (DATS) is a bioactive organosulfur compound derived from garlic (Allium sativum). Scientific studies, primarily in animal models and in vitro experiments, have investigated DATS for its lipid-lowering effects, including its potential to reduce high triglyceride levels. Research indicates that DATS may modulate lipid metabolism by influencing key enzymes involved in fatty acid synthesis and degradation, such as AMP-activated protein kinase (AMPK), and by enhancing antioxidant defenses. For example, several rodent studies have demonstrated that DATS supplementation can reduce plasma triglyceride levels, possibly by downregulating genes responsible for lipogenesis and upregulating those involved in lipid oxidation.

However, while preclinical data are promising, robust clinical evidence in humans is limited. Most human studies on garlic and lipid profiles use garlic extracts or powders rather than isolated DATS, making it challenging to attribute observed triglyceride-lowering effects specifically to DATS. Furthermore, the available human data on garlic's effect on triglycerides are mixed, with some studies showing modest reductions and others showing no significant effect. Thus, while there is a scientific rationale and preliminary evidence from animal studies supporting DATS for high triglycerides, the evidence base is not strong, and high-quality human trials are lacking.

In summary, the use of DATS to support or treat high triglycerides is scientifically plausible, but current evidence is limited. Further clinical research is needed to confirm its efficacy and establish appropriate dosing and safety in humans.

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