Evidence supporting the use of: Docosahexaenoic Acid
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Docosahexaenoic acid (DHA) is an omega-3 fatty acid primarily found in fish oils and marine algae. Its use to lower high triglyceride levels is supported by substantial scientific evidence. Clinical trials and meta-analyses have shown that DHA, especially when combined with eicosapentaenoic acid (EPA), can significantly reduce serum triglyceride levels in individuals with hypertriglyceridemia. The mechanism involves decreased hepatic very low-density lipoprotein (VLDL) synthesis and enhanced clearance of triglyceride-rich particles from the bloodstream.

Prescription omega-3 fatty acid formulations, which often contain both EPA and DHA, are approved by regulatory agencies (such as the FDA) specifically for the treatment of severe hypertriglyceridemia (≥500 mg/dL). Clinical studies, including randomized controlled trials, have consistently demonstrated reductions in triglyceride levels by 20-50% with omega-3 supplementation at doses of 2-4 grams per day. While both EPA and DHA are effective, some evidence suggests DHA may raise LDL cholesterol slightly more than EPA but is at least equally effective in lowering triglycerides.

Guidelines from the American Heart Association and other professional bodies endorse the use of omega-3 fatty acids as adjunct therapy for patients with high triglycerides, especially when lifestyle modifications alone are insufficient. Overall, the support for DHA's triglyceride-lowering effect is robust, making its use for this condition scientifically validated.

More about Docosahexaenoic Acid
More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

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algal oil
alpha-linolenic acid (ALA)
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anthocyanins
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arjun tree
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ashwagandha
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black currant
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broccoli
calamari oil
canola oil
catechins
chia seed
chokeberry
choline
coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
daidzin
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diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
flaxseed
fruit and vegetable blend (proprietary)
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niacin (vitamin B3)
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oleanolic acid
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omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
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palmitoleic acid
pantethine
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phospholipids
pine bark
plant sterols
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quercetin
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resveratrol
safflower oil
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sterols
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trans-pterostilbene
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Products containing Docosahexaenoic Acid

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